On the one hand "yous" fills this void in a way that is more consistent with the rules of pluralizing words, but on the other hand it also introduces a homophone with "use" which could hypothetically lead to confusion. So which is worse, inconsistency (y'all) or ambiguity (yous)?

Ultimately, since "yous" never fits in the same grammatical slot as "use" (different part of speech), there's never any real chance at confusion anyway. Therefore I weigh in on the side of "yous".

Once again New York has it right and the rest of yous be trippin.