not exactly, I ve played some games (last time was the metro 2033) under wine and cheat engine (under wine too) worked.
Also there is (linux) Gameconqueror/scanmem that work with wine games as well (you need to target the game's ".exe" process).
Gameconqueror works, but it is far inferior to cheatengine, especially with preset mem locations for various games (there is a ton of them on fearless revolution forum).
But CE never worked for me on Linux, quitting immediately. Maybe I'll give in another try when I have a chance to play.
I know what you mean, I had the same issues at the past with different distos/wine versions (I am on Fedora now). Also make sure you use the same WINEPREFIX for both the game/cheat-engine. It's a mixed bag anyway :(
