I think NoScript works best as an additional defence line and not as a primary protection mechanism. As such, I would of course still install all regular security updates. It does reduce my attack surface, though, even if it won't stand against dedicated attacks. At the moment it benefits from its rare use (compared to browser users in general) and if it became more widespread and targeted by mainstream attacks, I'm optimistic that the whitelist issue would sort itself out over time (by iteratively removing vulnerable or untrustworthy sites).
Btw., like a few others have noted for theirs, my whitelist does not contain those entries in question. It might be because my installation is relatively old and they weren't pushed retroactively.
If you are on Windows, an additional layer of security might be to install Sandboxie (http://sandboxie.com) and run Firefox from within a dedicated sandbox. Additional brownie points for editing the file/folder access. (making confidential folders inaccessible/write-only)
Btw., like a few others have noted for theirs, my whitelist does not contain those entries in question. It might be because my installation is relatively old and they weren't pushed retroactively.