I wonder if it's feasible to build a hosting site that strictly forbids (and actively removes) copyright infringing material, intended more for this kind of file hosting than for piracy.
Monetising would be a challenge, since rapidshare et al mainly made money by selling premium accounts, which are generally only attractive for piracy purposes.
Both require registration and are far more than just file hosts. The thing I like about rapidshare and other file hosts is that you can just drop a file on it and a minute later get a link. No thinking or effort required, no activation emails (or endless onboarding emails for that matter), no passwords to remember.
There's no such thing as "copyright infringing material", it depends on how has uploaded it. If I download an awesome ROM from megaupload using the link shared by its creator and upload it myself to megaupload to get my own link, the very same file is both infringing and not infringing copyright.
This is what people who were appalled that megaupload would only remove one of the links to a deduplicated file, instead of removing the file itself, failed (or refused) to understand.
Monetising would be a challenge, since rapidshare et al mainly made money by selling premium accounts, which are generally only attractive for piracy purposes.