My understanding was that it was impossible to eradicate Malaria in Africa because great apes could also be carriers, and treating every wild ape wasn't remotely practical.

Is that not the case?

Actually the only effective means of eradication I've ever been able to think up is an engineered virus... As it parasite it should be vulnerable to a viral weapon, and you could leave chickens with the virus in their bloodstream in Malaria infected areas.

But that could be my inner mad scientist trying to get out again.