A nice thing about Colemak is that is was designed to be somewhat compatible with Qwerty. Specifically, Z, X, C and V are in the same place, so those still work in shortcuts as well. For other shortcuts, I learnt them quickly enough, but it can sometimes be a bit more difficult when you are looking at the keyboard, it is confusing if the characters do not match. For example Ctrl+S is now Ctrl+D (the D on the Qwerty keyboard), and Ctrl+F is now Ctrl+E on Qwerty.