Antibiotics are done, and they've been failing increasingly for at least two decades even though nobody cared to report it then. The speed of our transition to the "post-antibiotics era" is certainly our fault, but the phenomenon itself was always inevitable. Biology is an arms race, and it will always be one. In fact, biology overall is one of the worst substrates imaginable for hosting conscious entities, and that means this and many other problems may never be permanently solved.
However, it's not all hopeless. There are a lot of bacterial infections that will continue to be treatable with antibiotics for some time to come. So it's not like we'll lose all of our capabilities at the same rate. It just means that gradually the number of strains that are panresistant will increase.
To see what complete powerlessness over an infectious agent looks like you don't have to look further than viral infections today. The reality is we still can't do very much to treat them, so over time we'll just add significant bacterial adversaries to this list of diseases for which there is nothing else but symptomatic treatment available.
This will all change, because medicine has to change. In the future, it won't be enough to hit an unspecific infection with an unspecific antibiotic. It will be necessary to analyze individual infections and their interactions with individual patients in detail - and then very specific biochemical treatments will have to be tailored on a case-by-case basis.
The recent rise of monoclonal antibody drugs is a bridge to that future. We're still not knowledgeable enough, and we're still using these treatments with all the finesse of a 3-year old hammering huge lego toys together, but we'll get there eventually. We have to, it's the only hope against a lot of other diseases as well, including cancer.
In the mean time, there is a lot of research that needs to be done. We're also missing the actual technologies, both diagnostic and generative machines, but the most important obstacle to overcome will probably be the culture of medicine. This culture will change only when there is enough pressure for it to change. The FDA will have to change when its primary role becomes denying treatment to people who are going to die instead of keeping the population safe. Medical professionals will change when it becomes a big factor that they lack the scientific background to effectively devise and apply advanced treatments. But first, all of these disasters will probably have to actually happen, and we're already seeing the first signs of that trend.
So, there is definitely a path forward - it's not an inevitable descent into the dark ages. It's just that due to inertia and time spent waiting for basic scientific advances, there will be a period with less protection overall. Drugs may become available to plug some of these gaps, like insect-derived antibiotics, which will eventually fail too but will buy some additional time.
However, it's not all hopeless. There are a lot of bacterial infections that will continue to be treatable with antibiotics for some time to come. So it's not like we'll lose all of our capabilities at the same rate. It just means that gradually the number of strains that are panresistant will increase.
To see what complete powerlessness over an infectious agent looks like you don't have to look further than viral infections today. The reality is we still can't do very much to treat them, so over time we'll just add significant bacterial adversaries to this list of diseases for which there is nothing else but symptomatic treatment available.
This will all change, because medicine has to change. In the future, it won't be enough to hit an unspecific infection with an unspecific antibiotic. It will be necessary to analyze individual infections and their interactions with individual patients in detail - and then very specific biochemical treatments will have to be tailored on a case-by-case basis.
The recent rise of monoclonal antibody drugs is a bridge to that future. We're still not knowledgeable enough, and we're still using these treatments with all the finesse of a 3-year old hammering huge lego toys together, but we'll get there eventually. We have to, it's the only hope against a lot of other diseases as well, including cancer.
In the mean time, there is a lot of research that needs to be done. We're also missing the actual technologies, both diagnostic and generative machines, but the most important obstacle to overcome will probably be the culture of medicine. This culture will change only when there is enough pressure for it to change. The FDA will have to change when its primary role becomes denying treatment to people who are going to die instead of keeping the population safe. Medical professionals will change when it becomes a big factor that they lack the scientific background to effectively devise and apply advanced treatments. But first, all of these disasters will probably have to actually happen, and we're already seeing the first signs of that trend.
So, there is definitely a path forward - it's not an inevitable descent into the dark ages. It's just that due to inertia and time spent waiting for basic scientific advances, there will be a period with less protection overall. Drugs may become available to plug some of these gaps, like insect-derived antibiotics, which will eventually fail too but will buy some additional time.