If you're using Filevault for full disk encryption you can't have Prey installed and use it on an open guest account. You can have a guest account and use the iCloud 'Find My Mac' though.
But that's exactly what I did on my last Mac (which wasn't using Filevault).
You use the guest account as a honeypot so they open the Mac and use it for long enough (without wiping it) for you to get a wifi connection and can get the location with Prey :-)