Every time I read comments on HN about how people have these "amazing" systems of filtering and labeling in gmail I always wonder if there's anyone else who uses gmail like I use it.... turns out there is and they've doubled my high score.
The owner of the (small) company I work at has 55k+ unread in his inbox. I suggested a few weeks ago he move to the priority inbox in an attempt to deal with the crazy inflow he manages.