https://www.rit.edu/news/rit-class-develops-applications-sup...
And, while not open source, built this: https://dirsig.cis.rit.edu/
Also, I remember some kind of early realtime music accompaniment software, the guy played trumpet and the software played realtime accompaniment.
Also, MIT built X11, which later turned into a bureaucratic exercise instead of software project.
Berkeley, well BSD Unix.
Early web projects came out of Michigan, like gopher.
Not much lately though.
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