I know someone who needs Meds A because of $SERIOUS_CONDITION (medical, not psych.)
They're on Meds B to deal with some side effects of Meds A.
They're on Meds C to deal with a side effect of Meds B.
They would like to be on Meds D to deal with a side effect of Meds C but Meds D are absolutely contraindicative with one of the other meds.
Out of the various combinations (no meds, Meds A, Meds A+B, Meds A+B+C, Meds A+B+C+D) they've chosen the one that is most bearable (Meds A+B+C) and they can live with the remaining side effects. The other options are worse. 'no meds' and 'Meds A+B+C+D' would mean death in the very near term, whilst 'Meds A' and 'Meds A+B' have some quite annoying and restricting side effects. 'Meds A+B+C' is the least worst option.
Anyway I have it and it's crippling.