I've never had ketamine. I've had memantine, but its half-life is ridiculous.
I self-medicate a variant of what's now available in the USA as 'Auvelity' but is just a ratio'd mixture of dextromethorphan and bupropion. The bupropion is there to slow down the metabolism of the DXM via its CYP2D6 pathway, but bupropion gives me anxiety/insomnia so I use something called berberine phytosome which isn't as effective but still works on CYP2D6 at a lower level, but no side effects.
All the other anti-depressant classes never worked for me but still gave me extremely shitty side effects.
There's a lot of anecdotal reports on DXM/Auvelity for both prescribed (variable outcomes, but for some people its the first thing that's ever worked), and recreationally its been around for ages sometimes referred to as the poor mans ketamine...
Not DID here, but schizo-affective. I've read things like meditation can actually have negative affects on dissociative disorders. Dissociating in order to re-integrate to a better place seems a somewhat reasonable strategy but I think mental-health/medication effects and understanding of how differently the same medications can affect different people is only just beginning to be realised by psychiatry now.
At least now there's even genetic testing for Auvelity - if you're already a poor CYP2D6 metaboliser due to a shortened version of a gene on a specific chromosome, they won't prescribe it to you. On the other hand you could be an ultra-metaboliser.
I self-medicate a variant of what's now available in the USA as 'Auvelity' but is just a ratio'd mixture of dextromethorphan and bupropion. The bupropion is there to slow down the metabolism of the DXM via its CYP2D6 pathway, but bupropion gives me anxiety/insomnia so I use something called berberine phytosome which isn't as effective but still works on CYP2D6 at a lower level, but no side effects.
All the other anti-depressant classes never worked for me but still gave me extremely shitty side effects.
There's a lot of anecdotal reports on DXM/Auvelity for both prescribed (variable outcomes, but for some people its the first thing that's ever worked), and recreationally its been around for ages sometimes referred to as the poor mans ketamine...
Not DID here, but schizo-affective. I've read things like meditation can actually have negative affects on dissociative disorders. Dissociating in order to re-integrate to a better place seems a somewhat reasonable strategy but I think mental-health/medication effects and understanding of how differently the same medications can affect different people is only just beginning to be realised by psychiatry now.
At least now there's even genetic testing for Auvelity - if you're already a poor CYP2D6 metaboliser due to a shortened version of a gene on a specific chromosome, they won't prescribe it to you. On the other hand you could be an ultra-metaboliser.
https://www.pharmgkb.org/gene/PA128/prescribingInfo