Huh. I’m at a healthy weight but I’m taking retatrutide for IBS and it’s working wonders. Very low dose, though. I originally tried it with semaglutide before the weight loss craze kicked off and the first few days of the week were worse and the latter half of the week was better, so that didn’t make sense for me to stay on.

With all of these long acting GLP's you will get a much smoother experience dosing them 2-3 times/week.

Maybe in the first few weeks, but their half-life is 7 days. You're not doing much besides making a hassle for yourself if your doing that after the first couple of weeks

The amount of "time on" is completely irrelevant. You will reduce peaks and troughs by injecting > once/week, this is a fact.

Yeah, I guess it's worth adding my relatively moderate side effect experience has been dosing 2-3x/week the whole time.

Can you say more about retatrutide for IBS? My IBS is debilitating to the point where I usually refuse to eat food on week-long work trips, because the unplanned emergency toilet trips wreak havoc with my schedule and ability to sit in meetings all day. I'd never heard there was a solution to it.

Sure, and I totally get your issues. I was a damned wedding photographer and I'd only eat towards the very end of the night, and still had a few iffy days.

As I stated, I originally tried semaglutide with no luck. I didn't try tirzepatide. I've been taking a very low dose of retatrutide - about .5mg twice a week. It seemed to be waning in effectiveness a bit so I upped the dose to 2mg/week for now. It's a night and day difference. Most days I go to the bathroom maybe two times, as opposed to the maybe 5-10 times I would need to unmedicated.

To be clear, this isn't an approved use of the medications (and retatrutide isn't approved at all yet, though it pretty clearly will be). However, they slow down gut motility - and as a bonus for your refusing to eat during week-long work trips, they'd probably at least help with that too, in terms of hunger.

I can tolerate tea quite well. Unseeetened iced tea by the gallon, specifically.

I'm not on any medications, and I've never been able to handle tea in the morning. Green, black, iced, hot, matcha. It always makes me feel nauseated unless I've eaten breakfast first. I always drink black coffee though, without problems.

I am similar. Green tea always makes me feel nauseous on an empty stomach. Tea with milk is normally ok.

That's why the Brits are having it ;-)

This is due to the high concentration of tannin in the tea. It causes stomach problems if you dont have protein in your belly already.