I don't think so. If your framework is high level enough, you've successfully outsourced the bad stuff to someone else.

But if you don't know the underlying platform, how can you be sure that your framework is high level enough or that it can do everything that's possible on the platform? You either have a framework with escape hatches (that'll require you to drop down to the bad stuff) or you have to wait until the framework catches up to the platform. Actually now that I think about it, React would fall in both camps.

You won't need to do "everything that's possible on the platform." You want to constrict yourself to the parts that work well.