I actually see this as an escape opportunity for F#-ers. I love the language, but the runtime and C# ecosystem are not only holding it back from having cleaner semantics (until the C# team sees the value in them), they've been actively kicking it down the ladder with breaking changes and new incompatible APIs.
Fable is the complete opposite direction to .NET and OxCaml, though. Nice for people doing web I guess (I'd rather do TypeScript than deal with interop), but the JS runtime and ecosystem are pretty much useless for my use cases.
Maybe a pure WASM target could actually liberate F#.