I was in a full arm cast (including fingers) for 9 months in college while taking many CS classes and I just used my one hand to type on the full qwerty keyboard. It definitely slowed me down, but I got up to ~60 wpm with the one hand. I think it's easier to just stick with the layout you know vs trying to learn to type with one hand in a new layout.

The nice part is that I can still type pretty quickly one-handed (maybe 50 wpm? Haven't measured in a while) and it's convenient sometimes.