Interesting!, thanks! —and also: I’m sorry you had to go through that
Had an experience with a missed type 1 diabetes diagnosis causing neuropathy in a loved one. There is a surprising amount of actionable scientific literature out on neuropathy and all sorts of other issues commonly discussed as best-you-can-do-is-wait-and-see. Once you happen to dig in and start reading.
I remember reading papers on acetyl-L-carnitine helping with diabetic neuropathy, and it was our clear experience that it did help.
There were other supplements which helped with various similar repercussions of a severe and prolonged state of elevated blood sugar, which causes oxidation and tissue damage, and isn’t dissimilar to B6 toxicity as it seems. I don’t remember exactly which nutrients/OTC medications seemed to help neuropathy, but I’d suggest looking into alpha lipoic acid (ALA; more specifically Na-R-ALA), argine, maybe BCAAs in the context of mitochondrial function. Probably some other stuff that has results out on it too.
I’d also suggest reading the molecular biology and neuroimmunobiology on NMDA receptor antagonists and 5-HT2A receptor agonists, classes both of which are shown to be “profoundly immunomodulating” as one paper put it – reducing inflammation, including neuroinflammation – as well as encouraging neuroplasticity, which is also useful in peripheral nerves. The discussion of these known molecular-biological results and implication is unfortunately swamped by various social effects; the best-known NMDA receptor antagonist is called “Ketamine”, haha, and 5-HT2A agonists are usually known as psychedelics and, uh, yeah… molly. The partying and the “wheeee” factor isn’t interesting to me; the neuroimmunobiology of it is!! And I, yeah, I emphatically recommend reading the scientific literature on that.
And generally looking for recent papers on nutrients/supplements/OTC medications in the context of all kinds of similar issues. There are often results in one sub-specialization which are applicable to other things. You don’t need to limit yourself to randomized controlled trials, especially
if considering supplementation of compounds known to be safe, rather than medication; Molecular biology is molecular biology, and it’s implausible to me that the placebo effect will reliably improve things like chronic neuropathy. Or insulin sensitivity. I’ve seen direct results on continuous glucose meters and all manner of labwork that confirm this view. —Don’t believe me; I deeply and emphatically recommend reading academic literature.
To paraphrase a nice-seeming guy,
Read papers. Mostly published. Not too slowly.
ps.,
Claude is unusually good at navigating the scientific landscape!
Had an experience with a missed type 1 diabetes diagnosis causing neuropathy in a loved one. There is a surprising amount of actionable scientific literature out on neuropathy and all sorts of other issues commonly discussed as best-you-can-do-is-wait-and-see. Once you happen to dig in and start reading.
I remember reading papers on acetyl-L-carnitine helping with diabetic neuropathy, and it was our clear experience that it did help.
There were other supplements which helped with various similar repercussions of a severe and prolonged state of elevated blood sugar, which causes oxidation and tissue damage, and isn’t dissimilar to B6 toxicity as it seems. I don’t remember exactly which nutrients/OTC medications seemed to help neuropathy, but I’d suggest looking into alpha lipoic acid (ALA; more specifically Na-R-ALA), argine, maybe BCAAs in the context of mitochondrial function. Probably some other stuff that has results out on it too.
I’d also suggest reading the molecular biology and neuroimmunobiology on NMDA receptor antagonists and 5-HT2A receptor agonists, classes both of which are shown to be “profoundly immunomodulating” as one paper put it – reducing inflammation, including neuroinflammation – as well as encouraging neuroplasticity, which is also useful in peripheral nerves. The discussion of these known molecular-biological results and implication is unfortunately swamped by various social effects; the best-known NMDA receptor antagonist is called “Ketamine”, haha, and 5-HT2A agonists are usually known as psychedelics and, uh, yeah… molly. The partying and the “wheeee” factor isn’t interesting to me; the neuroimmunobiology of it is!! And I, yeah, I emphatically recommend reading the scientific literature on that.
And generally looking for recent papers on nutrients/supplements/OTC medications in the context of all kinds of similar issues. There are often results in one sub-specialization which are applicable to other things. You don’t need to limit yourself to randomized controlled trials, especially if considering supplementation of compounds known to be safe, rather than medication; Molecular biology is molecular biology, and it’s implausible to me that the placebo effect will reliably improve things like chronic neuropathy. Or insulin sensitivity. I’ve seen direct results on continuous glucose meters and all manner of labwork that confirm this view. —Don’t believe me; I deeply and emphatically recommend reading academic literature.
To paraphrase a nice-seeming guy,
Read papers. Mostly published. Not too slowly.
ps., Claude is unusually good at navigating the scientific landscape!