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We don't know yet whether the muscle loss is caused by the drug itself or due to the weight loss, there are some studies but I haven't seen any conclusion yet one way or the other.

Anecdotally, a friend of mine was on a diet and exercise regime, then at some point he switched to Mounjaro to reduce cravings, while keeping the same diet and exercise regime (he's a data geek so he documented things pretty well), and his muscle gain maybe slowed a tiny bit, but didn't reverse on Mounjaro.

Sample size of one, but at least it's not zero.



Also sample size of one, but with the weight loss from semaglutide, I've gotten back in the gym and I can now lift more weight than I ever have. It feels fantastic (both the weight loss and being strong)


Same for me. Though I started weightlifting 3x a week to combat any potential muscle loss.

I cycle frequently and the impact of the weight loss and added strength has made me feel much faster this year (and it's still rainy/cold season).


I envy you. I tried three times and got bad side effects each time, so I've given up :(


I feel for you, friend. The safest way, however, is to make hunger your friend, and walk an hour or two a day. That may not work well with your work schedule, but you can override your body with your mind, unless your mind suffers because of our tech work's energy needs.

And, it takes me a day or two to get past a processed sugar addiction. After those couple of days, the body starts getting used to not having that "crack" energy source be a part of its desire-base.

Good luck, stavros, you can do it! And the sooner you start, the quicker you can get over the initial hump of resistence. Perhaps you can carrot yourself along by knowing that you WILL feel much, much better as the pounds start coming off and your body starts being able to walk a bit further or lift a few more weights. Fight the food inertia, my brother.

If you really want extra help, contact the Creator of the universe in the morning and evening, and ask It for help. If you do that with an intention to be able to better help others, you will find that the universe, itself, will become your ally.




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