We have a lot of correlations and theories and now we can test over more than 10 years and see what happens when with patients where we have successfully kept these markers down from a much earlier start. I just hope they control correctly for brain bleeds and premature death.
As far as I'm aware, we currently have no evidence to suggest whether the appropriate model for this protein accumulation is more "it's like a cancer growing on your organ" or "it's like a scab growing over an open wound".
Are scabs markers of injury? Of course.
Could we reduce injuries by preventing the development of scabs? No, that's a new horrifying medical condition called hemophilia. In the general case, it's rapidly fatal.
This is something that really bothers me about the current craze for suppressing inflammation. In that case, we already know that inflammation is like scabs, a defensive reaction against some other problem. For Alzheimer's, we don't know anything.
