It is very popular in gamedev space whenever using C# as a high-performance scripting language.
You are right to say this is low-level though, but low-level scenarios are not as niche for .NET platform as they are for other languages in this category.
- As full runtime i.e. hostfxr https://learn.microsoft.com/en-us/dotnet/core/tutorials/netc... (supplementary: https://github.com/StudioCherno/Coral)
- As a dynamic library via DNNE with full runtime: https://github.com/AaronRobinsonMSFT/DNNE
- As either dynamic (easy) or static (hard) native library: https://github.com/dotnet/samples/tree/main/core/nativeaot/N...
There are a few community projects which build on top of these to provide a more seamless integration with other languages.