I don’t have a lot of experience with this, but that’s mainly because there’s no way to compile my company’s application with Native AOT. At least not without a significant amount of work.
This is because there are many limitations in what can be compiled this way, and most C# applications and libraries were never built with such limitations in mind.
AFAIK, the limitations are just some (not all) reflection API is missing, and trimming can cause problems. That’s pretty much about it. Obviously it’s a problem if you need those, but I wouldn’t call it “many limitations”.
This is because there are many limitations in what can be compiled this way, and most C# applications and libraries were never built with such limitations in mind.