You can receive something a certain way that was not intended by a sender.

It's important to try to understand the intent of the sender. In this case, many cultures sending the message "you guys" don't internally view this as relating to gender.

You could try to change their culture because many people receive it wrong, or you could learn about the culture and try to change the receivers culture.

Sometimes you can't accept the differences because it's perpetuates too much harm.

Where to draw the line is an ongoing and difficult question.