"COVID-19 vaccination of the index case reduced infectiousness by 44% (95% CI, 27-57%), vaccination of the close contact reduced susceptibility by 69% (95% CI, 65-73%), and vaccination of both reduced transmissibility by 74% (95% CI, 70-78%) in social settings, suggesting some synergy of effects."
"Conclusions: COVID-19 vaccination reduces infectiousness and susceptibility; however, these effects are insufficient for complete control of SARS-CoV-2 transmission, especially in older people and household setting."
Overall, I think the dominant phenomenon here is people wanted to typecast floating-point data to boolean answers, the media did their best to accomodate that want, and almost nobody reads primary sources.
You'd have to ask the Pfizer / BioNTech press staff, since they were the source.
Later down in this article, they clarify with some hard numbers: "Researchers observed 18 Covid-19 cases among the 1,129 participants who were given a placebo, and none among the 1,131 volunteers who got the vaccine. The data has yet to be peer reviewed."
So Pfizer/BioNTech is reporting 100% efficacy on a non-peer-reviewed study where 1.5% of the control group contracted the disease (news article doesn't say how "contraction of disease" was identified, whether that was antibody presence or symptoms).
News has a bad habit of reducing complex circumstances to headlines that appear yes-or-no.
It would be good to point out William Makis is a disgraced, long unlicensed (pre pandemic) physician and anti-vax grifter, a quack.
Quite telling he still claims affiliation with an institution he was terminated from nearly a decade ago.
He worked at a cancer center as a radiologist but continues to misrepresent his expertise as an oncologist. Real piece of work.
Glancing at this article you have posted, I am genuinely intrigued and look forward to reading it today or tomorrow.
The thing about the IgG4 topic overall, is it's not just a small handful of papers that are discussing it, along with other immune issues that have resulted from the mRNA shots.
> It would be good to point out William Makis is a disgraced
Can you give us a solid citation on exactly how? I would like to see this.
> He worked at a cancer center as a radiologist but continues to misrepresent his expertise as an oncologist.
This means he had a front row seat to how cancer develops in patients, how cancer is successfully neutralized (or not) in patients, and also the internal politics and realpolitik imperatives of such a place. Given that cancer is a multi-hundred billion dollar industry, and a patient cured or prevented from having the disease in the first place is not profitable, unironically his work history could provide insight into how institutions that employ fleets of oncologists actually operate.
"Conclusions: COVID-19 vaccination reduces infectiousness and susceptibility; however, these effects are insufficient for complete control of SARS-CoV-2 transmission, especially in older people and household setting."
https://pubmed.ncbi.nlm.nih.gov/36724697/
Overall, I think the dominant phenomenon here is people wanted to typecast floating-point data to boolean answers, the media did their best to accomodate that want, and almost nobody reads primary sources.