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I assume you are also on weekly doses. How does it work for you?

I feel like I go through cycles of:

Day 1: no change

Day 2: can go whole day without eating, a bit nauseous

Day 3-5: feeling bloated, food doesn’t digest fast, not eating much, biggest weight loss

Day 6-7: Slowly getting back to eating reasonable portions




I feel like I have an almost optimal reaction to the drug, which I kind of feel bad about, given all the side effects other people seem to have. My experience mostly matches yours, except without bloating or nausea. I do have a slight urge to drink on day 6 and 7 -- well not an urge, more like an acceptance of it -- kind of hard to explain. I don't even think about alcohol on the other days.

I am injecting the Hims formulation of semaglutide. I had no side effects on my first two injections, so my next two (which were supposed to be the same as the first two) I increased the dosage slightly. I am pretty happy with how I feel so I'm not sure how aggressively I'll ramp up to the full dose.


I’m on Zepbound and I had no side effects for my 2.5mg and 5mg doses. It’s starting to be more prevalent with 7.5mg - and I haven’t moved to higher dose yet.


Ah, ok so my experience parallels yours.

Are you eating "healthier"? What I've found is I prefer "simpler" meals to more complex/layered/richer dishes. I forgo pasta dishes or sandwiches for simple meals like eggs + a vegetable + fruit. I've actually had to throw out a bunch of ingredients that went bad that I never would have had to before. I've had to adjust my grocery shopping quite a bit, including frequency.


Yes, simpler is better. More specifically, I no longer can do Thai food. To spicy now.


I'm on 1mg of compounded semaglutide, where I've been for the past 4 months. I have a similar arc in terms of days 2-5 being the strongest effect, but I haven't experienced any nausea (except the smallest bit during the first couple of weeks at 0.5mg.) I was briefly at 1.5mg but was brought down because I started losing weight faster than needed. My weight has been rock steady since coming back to 1mg.


That's usually how it works for me too. I find that days 2-5 I start feeling not very good. I wouldn't say bloated, but almost weird blood sugar levels.

Usually about 6pm in the evening is when I start feeling terrible. Kinda makes me want to eat less.


It works much better, in my experience, to cut the dose in half and take it twice a week. I do Sunday and Thursday, 2.5mg of tirzepatide per injection.




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