The obesity epidemic is only 50 years old.
GLP-1 seems to be a “thing that fixes your satiety balance”, that is applying to more than just food, but maybe also help you regulate yourself when you have way too much access to alcohol, drugs, etc.
In short: the reason that the human body wouldn’t have evolved to make more GLP-1 automatically yet is because evolution causes populations of organisms (not individuals) to change, over generations, to be better suited to their environment.
And 50-100 years is nothing in terms of evolution. We spent 500k years evolving to optimize gathering every calorie we can. And then yesterday it turned out that maybe it is in fact possible to have too much.
Also, the human body does make some GLP-1 itself. Maybe it was just getting started.
In short: the reason that the human body wouldn’t have evolved to make more GLP-1 automatically yet is because evolution causes populations of organisms (not individuals) to change, over generations, to be better suited to their environment.
And 50-100 years is nothing in terms of evolution. We spent 500k years evolving to optimize gathering every calorie we can. And then yesterday it turned out that maybe it is in fact possible to have too much.
Also, the human body does make some GLP-1 itself. Maybe it was just getting started.