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> If it was that simple, why didn't the human body just evolve to excrete GLP-1 agonists? Or modify GLP-1 itself?

Replace "GLP-1" with any of: aircraft, computers, buildings, WiFi, ...

Some things are easy for nature to find and some things aren't!

And even of the things that are easy for nature to find, and that we would have found useful even in the environment of evolutionary adaptation, they might not confer overall fitness if they are too costly.




Well said. Diseases that affect the elderly don’t get a lot of consideration from nature. Natural selection really only cares about us reproducing.

On top of all that, our current environment and diet are quite a bit different from the norm over the past few million years.




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