I think this line of reasoning does a disservice to all the scientists and thinkers who contributed to a considerable amount of knowledge. We learned so much about the universe in the past 100 years, it's impudent to call this nothing just because it's not everything.
I'm talking about filling in the blanks in things that are not yet known, not discounting all scientific progress. The point was that the person I replied to held just as irrational a belief as the person they were criticizing. Neither of them knows the deeper nature of reality and whether humanity was created by something or is just an accident of nature, so both of their replies are absurd as one another's.