There are some concerns with retatrutide - it's popular among the bolder people willing to buy it as a research chemical, and both their reports and the clinical trials do show significantly higher resting heart rates as a common side effect.

Not a huge deal for people that have good heart health already, but since obesity tends to cause poor heart health...

I expect we'll still get it approved for weight loss use, but it'll be one that is going to take more observation on the patients using it