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> Even for cutting edge CS/statistics fields like high level machine learning, most of the calculus used are existing formalisms on multidimensional statistics and perhaps differential equations.

If you mean experimental work, then sure, that's like laboratory chemistry. You run code and write up what you observe happens. If you're trying to prove theorems, you have to understand the epsilon delta stuff even if your proofs don't actually use it. It can be somewhat abstracted away by the statistics and differential equations theorems that you mention, but it is still there. Anyway, the difficulty melts away once you have seen enough math to deal with the statistics, differential equations, have some grasp of high dimensional geometry, etc. It's all part of "how to think mathematically" rather than some particular weird device that one studies and forgets.



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