>even with infrequent usage, and by following proper instructions, liver toxicity could still technically occur within just 24 hours of usage.
Sorry, I find it hard to understand how you came to this conclusion. Even if taken every 4 hrs for the whole 24h (which is extreme case, rarely one needs more than 2-3 tablets for a pretty nasty fever) it gives us 6 doses per 325 mg = 1950 mg which is well below even the most cautious limit
It is often taken for long term chronic pain as opposed to a occasional fever as well. Could easily take 6 500mg pills a day for a long time. Add some drinking on top.
Sorry, I find it hard to understand how you came to this conclusion. Even if taken every 4 hrs for the whole 24h (which is extreme case, rarely one needs more than 2-3 tablets for a pretty nasty fever) it gives us 6 doses per 325 mg = 1950 mg which is well below even the most cautious limit