Hacker Newsnew | past | comments | ask | show | jobs | submitlogin

It only lowers muscle mass and bone density because your body only secretes the bare minimum amount of insulin needed to maintain while on it. Put another way, you want insulin sensitivity when you cut, but you want insulin resistance when you bulk. If you know what you're doing it can greatly increase your strength and lean body mass. I took compounded semaglutide for one week, cut about 15 lbs, then bulked 45+ lbs over the next few months.


How do you increase your lean body mass while on it?


Bryan Johnson protocol - testosterone and weight training.


Oof, testosterone comes with a ton of downsides (your body will stop making its own). We are really careful about people who start on testosterone replacement therapy, as it's a lifelong thing.


What’s interesting is that Bryan himself claimed to have stopped TRT and was able to restore his levels to baseline levels. I have clinical hypogonadism so I was probably going to need lifelong TRT anyway. My LH and FSH were normal but testosterone and estradiol were both low. It was a sudden drop too.




Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: