The calibration to get just 2 sticks to be stable is around 20-50 seconds already, during which the memory controller is testing different sequencing and even clocks for individual lanes to minimize interference. So unless you want to stop the entire CPU if you need that memory, no.

You're running a signal at 2.4+ GHz (commonly 3 GHz for DDR5-6000) over 288 pins over several centimeters simultaneously, it's not pretty.