I would think you would treat the OpenRESTy component as just an executable binary application server just as you would with any other webservice, and put your nginx stuff in front of it, just like you would with any other webserver's front end lb. I agree that it does sound nice to handle it as another component in a regular nginx config, but it doesn't sound like a dealbreaker. Just treat the nginx stuff as incidental to the implementation and it seems like it would be no big deal.