One of my favorite uses of uBlock Origin has been to turn off the comments and recommended videos on YouTube. I'll probably have to recreate my filters after this, but other than that it won't affect me much.
I highly recommend it! Even if you don't use any ad lists at all, being able to eliminate distracting elements of frequently used sites is a huge QoL improvement.
I like the Enhancer for YouTube plugin that blocks all that, and also automatically sets the resolution, makes the video take up the whole browser widow without going fullscreen, and allows speeds greater than 2x
I highly recommend it! Even if you don't use any ad lists at all, being able to eliminate distracting elements of frequently used sites is a huge QoL improvement.