A lot of things become simpler, but hard problems remain. In the cell, a structure of a protein is the result of its sequence and all the other environmental conditions (cofactors, ligands, binding partners, lipids,…), and furthermore, the structure is a dynamical construct, so it can change over time. So the main advance for society is when we can accurately predict how to jam or unblock a machine in a cell without influencing all the other machines in a cell. The essential pieces of this puzzle are the possible shapes of the pieces that make up the machines and AF2 gives you those. But the puzzle is huge. And very important.