Absolutely. The same is true for bug reports: if you always approach any bug report with the possibility that it may be your mistake, 1) you avoid annoying someone if it is your mistake, and might actually get helpful advice, and 2) you're more likely to get a cordial reception for real bugs.
You don't have to be excessively self-effacing about it, just avoid presenting things as though the project you're reporting it to being at fault is the only possible conclusion.
It's also important to consider how what you view as a bug might not be one from the point of view of the person treating your issue. It is so, so infuriating to receive a "bug" report asking you to "fix" something that is in fact a feature request for something that is not implemented yet.
Even if you get an error from the software, consider that you might not be using it as intended or setup properly.
You don't have to be excessively self-effacing about it, just avoid presenting things as though the project you're reporting it to being at fault is the only possible conclusion.