I installed Qubes OS last year. First, the installation was not smooth. I had to play with the UEFI BIOS settings to get the installer work. It can be picky with respect to hardware. That’s OK, but it’s unclear what works and what doesn’t, and you have to spend time searching the internet. If you look at their FAQs and forum, you will find all sorts of known problems that may arise just around the installation and booting. Then, the updates sometimes failed (and were slow, but that was OK). The main problem was that after a short while, one day it stopped booting, and I had to spend time in forums again. It felt unpredictable and fragile.

For an operating system to be used as a daily driver, it has to be stable, and reliable. The laptop may be forced to shutdown, even during an update installation. Some functions should always work: boot, WiFi/ethernet, HDMI, etc.

I would love to replace desktop Linux with Qubes. I work in Qemu VMs anyways. I would probably give 4.2 another go.