> According to her, a lot of overdoses are due to almost no "heroin" actually being heroin, rather its fentanyl cut to varying degrees of strength.
Anyone knows that who followed current events during the opiod epidemic and read some Wikipedia on it.
And actually, it's not just fentanyl, but fentanyl-like compounds that, even if controlled to the same concentration, have varying degrees of strength.
"The structural variations among fentanyl-related substances can impart profound pharmacological differences between these drugs, especially with respect to potency and efficacy"
You don't know which fentanyl analog is in that heroin dose, and how much of it.
It’s a lot, but not a crazy amount. Chemistry scales combinatorically, so if you find a single nitrogen to put a little e.g. acidic group on you’ve got yourself a couple of hundred possible substituents, many of which may have a similar effect on the body.
Anyone knows that who followed current events during the opiod epidemic and read some Wikipedia on it.
And actually, it's not just fentanyl, but fentanyl-like compounds that, even if controlled to the same concentration, have varying degrees of strength.
https://en.wikipedia.org/wiki/List_of_fentanyl_analogues
"The structural variations among fentanyl-related substances can impart profound pharmacological differences between these drugs, especially with respect to potency and efficacy"
You don't know which fentanyl analog is in that heroin dose, and how much of it.