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And B6 overdose causes small fiber neuropathy. It’s advisable to get levels checked before supplementing. I‘d consider getting the active form (P5P) as it also works when metabolism is impaired. Another thing to note is that those supplements often come in very high doses (eg 100x the DRI), which I personally wouldn’t take to avoid toxicity.


B6 toxicity is absolutely no joke. https://understandingb6toxicity.com/b6-toxicity/symptoms/

Can take months to years to recover from. I've had it myself, had all kinds of symptoms including peripheral neuropathy. Couldn't feel my fingers. Took me ~6 months to recover full feeling in my fingers and toes. It's literally the reason I don't take supplements now.


Sorry to learn about your bad experience. Toxicity is vastly different for the different minerals and vitamins though, just need to inform yourself up front.


Yeah I agree, I was being hyperbolic because I wrote that from my phone while walking around so didn't want to spend the time elaborating.

I still take two supplements nearly daily. Those being choline and d3. Every now and then magnesium. However my first hand experience with toxicity as a result of nothing more than my attempt at gaining some type of insurance policy against bad health really caused me to reevaluate supplements and respect them in the same vein as any other drug.

So now, I refuse to supplement anything until I can prove deficiency and a need with a blood test. In other words, spending the 50-100$ on a blood test is now my insurance against repeating my mistake.

Unfortunately I can't test for choline status however I still supplement it based on my genomics and because it makes a clear difference in my cognitive function.


Interesting, choline isn’t something that I can take indefinitely. It can induce depression actually, depending on metabolism.


Yes yes yes. B6 levels can get extremely high with the amounts in many B complex capsules, let alone the B6 specific. Take it easy on B6 unless you actually know your levels. More is not always better.


I'd say always supplement with P5P, never with B6. Although some may argue it's safe in small amounts.




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