Well that’s even worse. You have to be on it continuously? I thought it was just before any planned sexual encounters? They’re basically ARTs and wreak havoc on the body (10x increase in cancers- that’s a 1000%, neurological damage etc.) over time.
Nope, prep is well tolerated by the vast majority of individuals, although in rare cases it can reduce kidney function and bone density — However, the prescription requires regular lab testing (Where they also run STI tests as well), and if issues are found, there's two options:
1: Getting off prep, in which case kidney/bones should return to normal.
2: Switching to a newer version of prep called Descovy (in the US), which is has less of the aforementioned side effects, but is more expensive because there is no generic for it yet, and may not be covered by some insurances.
Although technically not sanctioned in the US (IIRC), the 2-1-1 method can also be an option for planned encounters: 2 pills 24hrs before the encounter, and 1/day for 2 days after the encounter.