Sponsorblock already exists as infrastructure to slice out ads embedded into the video streams themselves. Of course, the sponsor segments weren't put there by youtube, but the same (or similar) solutions would apply if they were.
Sponsorblock would be easy to work around if ad-breaks were randomly selected. Whenever you upload a video YT could process the video and "search" for good ad-break locations, at display time client bits get pushed ads randomly, making time-code blocking useless.
They could even upsell to content creators by giving them the means to dynamically replace sponsors in old videos using the same tech, maybe with some knobs and switches for content creators to select where sponsor breaks occur.
Maybe someone could use train a AI for something useful like skipping advertisement? Switching from time to content id, i.e. like they use for copyright strikes, would work even better than status quo.
The ads don't always have to be injected into the exact same parts of a video, and YT can also choose not to stream any more bits until it thinks something's been "watched".
It already behaves this way if you aren't blocking ads. If you seek too far ahead in a video with mid-video ads, it'll show an ad before playing at the timestamp you selected. If they want to prevent ad-blocking, they can do the same thing except not serve the video ahead of time.
It's much easier for anything non-live.