The majority of sites that I've seen using Project Wonderful gave been online comics, and since that's a big market for the site, I personally couldn't recommend it for just anyone. While I do think the idea behind it is really nice and a great way to promote smaller advertisers, I've only been able to sell ad space really cheaply since a lot of markets are just underrepresented. Makes me sort of wish PW was a bit bigger.
never used it personally but it was recommended to me by someone that had for a mid volume site.