If I tell you that I'm rolling a die, and ask you whether I rolled a six or not a six, offering you 100$ if you guess right, you very obviously should say "not a six", even if we only play the game once.
No, reading Taleb I realized that if it's not repeated it’s just a guess and winning or losing is a 50/50 thing. There is no strategy because the game doesn’t last long enough for strategy to matter. [/s]