I agree certain knowledge may be unattainable, but I don’t care. Useful effective knowledge that helps me achieve my goals in life will do just fine. As long as my mental model of the tree is accurate and useful enough for me to chop it down and make a table out of it, I’m good.

I don’t expect any description to accord perfectly with the reality of the object it refers to. It’s just a description, which may be more or less accurate or useful. Science, and investigation in general, is a way to test and improve such descriptions.