A downside with these off-QWERTY keyboard settings is that (as he mentioned) the shortcuts are often designed for QWERTY keyboards - things like X C V, sure X might be cut, and C is kinda copy, but V is not paste.
To really "go whole hog" you have to either remap the shortcuts to be the same positionally, or rethink the shortcuts from first principles.
I believe what I used to do was set it up where CTRL worked to also revert my keyboard to QWERTY mode, so all your muscle memory for shortcuts on QWERTY still work, but typing is in the other layout.
At the end of the day, I found I'd sort of bound "Copy" or "Save" to a key combo in my mind that was somewhat unrelated to the specifics of where C or S were on the keyboard for typing, so it didn't really hurt my uptake of the new typing layout.
To really "go whole hog" you have to either remap the shortcuts to be the same positionally, or rethink the shortcuts from first principles.