I'm sure it's fueled by xenophobia, but if we think of China / US as competing technology firms, the decision makes even more sense. What tech firm would want a one-sided relationship where their employees share information using a competitors platform, when you have no guarantee of privacy?
I don't think the walled isolation claim sticks - the US would not be seeking to isolate itself. Instead, it would be requiring both countries to operate on the same playing field. Why would anyone want to play a game when the other side won't agree to the same rules?