It can be more of an issue if you have a lot of "smart" products or IoT products that essentially operate as black boxes on your network though. Would just recommend not doing that, if you have devices on your network that you don't control, someone else does.
That only affects things that use the browser's facilities to engage in DoH. A web page could decide not to do that, and manufacture their own lookups using JS, for instance.
It's actually not too difficult if your users use Firefox. You can use enterprise policies https://support.mozilla.org/en-US/products/firefox-enterpris...
It can be more of an issue if you have a lot of "smart" products or IoT products that essentially operate as black boxes on your network though. Would just recommend not doing that, if you have devices on your network that you don't control, someone else does.