Very in my opinion, but I'm coming from a bike packers perspective.
Start the route tubeless and run it until it fails. When that happens throw a spare tube (that you should be carrying anyways) in it. If that goes flat, patch it.
Converting back to tubes is easy: take the value stem out -> put in tube. Yes, it's messier but it's not like you're showering regularly anyways.
> Being able to locally resupply with a compatible sealant is the main impediment
I would think that tubeless setup + plugs with spare tubes + a patch kit would get you far enough for this to not be a major issue. Carrying a small bottle of sealant would help. Worst case, you run tubes the rest of the trip.
Note: These are just my thoughts as a (formerly) sponsored bike packer.
Very in my opinion, but I'm coming from a bike packers perspective.
Start the route tubeless and run it until it fails. When that happens throw a spare tube (that you should be carrying anyways) in it. If that goes flat, patch it.
Converting back to tubes is easy: take the value stem out -> put in tube. Yes, it's messier but it's not like you're showering regularly anyways.
> Being able to locally resupply with a compatible sealant is the main impediment
I would think that tubeless setup + plugs with spare tubes + a patch kit would get you far enough for this to not be a major issue. Carrying a small bottle of sealant would help. Worst case, you run tubes the rest of the trip.
Note: These are just my thoughts as a (formerly) sponsored bike packer.