Have you ever tried writing a native client? I think the native client path is something that a lot of developers don't even consider these days. I think it's an area of great opportunity.

What do you mean? Like writing one's own framework, such as devoutsalsa.js?

I have no idea what that is, but since it's javascript I assume it's still running in the browser.

I'm suggesting getting out of the browser all together and writing a native client. Before Evernote moved to Electron, it's what they did. Their Windows client was written in C++ and their Mac client was Objective C.

I’m a fan of building with vanilla JS and I agree 100%.

It can be simpler, but it can get out of hand just as easily as any front end framework.