I guess it depends on how you do it. Depending on how I've set things up, I've found that more samples isn't necessarily better (usually just different). I suppose it's an optimization problem. I have found that I can pretty reliably look at a 1 sample image and kinda guess where the earliest iterations are going to go, and that might be the most appropriate workflow, actually, but beyond that it seems a couple of samples can drastically alter outputs, and likewise with prompt editing. Whereas with img2img there's a lot more control, I pick an input, I can force it to strictly abide to the image and the parameters I want, and as someone else said in- and outpainting are nice as well.

I guess I'm just manipulating probabilities in my favor?